But Sinner soon quashed those dreams, breaking back as Fritz attempted to serve for the set and doing the same two games later to wrap up the win after two hours and 16 minutes.
It was more straightforward in New York as he rarely looked troubled by Fritz, who struggled to build any momentum.
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Sinner said the title "meant so much because the last period of my career was not easy" before he became tearful and dedicated the victory to his aunt.
"He's stepped up a role and I feel like he's taking everything as seriously as he can and fair play to him, that shows he wants to stay."
Sinner was ruled to bear pelo fault or negligence for the positive tests by the International Tennis Integrity Agency (ITIA), which found he had been inadvertently contaminated by his physiotherapist.
It marks a new era of tennis as 24-time major winner Novak Djokovic, who was knocked out in the third round, ends the year without a Grand Slam title for the first time since 2017.
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Just six days before the main draw got under way, it was announced he had twice tested positive for low levels of a metabolite of clostebol - a steroid that can be used to build muscle mass - in March.
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It has been nearly 50 years since a man won their first and second Grand Slam titles in the same season, and Sinner is now a long way clear of the rest at the top of the rankings.
He was not at the peak of his powers for the entire two weeks, but still only dropped two sets and saved his best for the final.
Cheered on by a home crowd packed with celebrities and sporting stars, Fritz got off to a shaky start when he dropped serve in the first game.